Phytosphingosine (PS) is a key molecule in the natural defense mechanism of the skin. It is a component of ceramides, 40-50% of the main lipids responsible for 1) maintaining the cohesion of the stratum corneum, 2) controlling local flora, and 3) maintaining the correct moisture balance.
  • Naturally present in skin
  • Highly effective on seborrheic conditions
  • Antimicrobial
  • Anti-inflammatory

          
Key properties of phytosphingosine
Control of superficial bacteria and fungi



Control of inflammation
   • Anti-IL1 activity, which impairs the production of PGE2
   • Inhibition of kinase protein C
Repair of skin's defense system
   • De novo synthesis of ceramides restores healthy balance
Phytosphingosine is a patented biotechnology product, introduced to the U.S. veterinary market by Sogeval Laboratories, one of the world's fastest-growing animal health companies. With its DOUXOŽ line of phytosphingosine-based products, Sogeval has made it possible to reduce the number of shampoos necessary to treat dermatologic conditions by incorporating complementary new dosage forms such as a micro-emulsion spray, spot-on solution and gel in spray form. This easier protocol leads to better compliance by the pet owner and improved efficacy in controlling common dermatologic conditions.

This revolutionary molecule is much more than a new active ingredient. Phytosphingosine is the molecule with the broadest spectrum of activity in veterinary dermatology.

DUOXO's Phytosphingosine (PS) is the Molecule with the Broadest Spectrum of Activity in Veterinary Dermatology.
References:

Wohlrab J, Jost G, Abeck D. Antiseptic Efficacy of a Low-Dosed Topical Triclosan/Chlorhexidine Combination in Atopic Dermatitis. Skin Pharmacology and Physiology 2007;20:71-75.

Waller JM, Dreher F, Behnam S, Ford C, Lee C, Tiet T, Weinstein GD, Maibach HI. Keratolytic Properties of Benzoyl Peroxide and Retinoic Acid Resemble Salicylic Acid in Man. Skin Pharmacology and Physiology 2006;19:283-289.

Carlotti D-N. The Art of Shampooing in Canine and Feline Dermatology: Therapeutical and Preventive Strategy. PMCAC 2004;39:7-15.

Bensignor E. The Rational Use of Shampoos in Dermatology. 1996.

Additional references and data on file with the company